Role of miRNAs in endometrial cancer.

نویسندگان

  • Shuangdi Li
  • Jiarong Zhang
  • Xiaoping Wan
چکیده

Endometrial cancer (EC) is the most common gynecologic malignancy. MicroRNAs (miRNAs) were recently associated with carcinogenesis and progression of EC. In this review, we discuss recent advances and the emerging role of miRNAs in EC and their clinical implications, with special emphasis on the differences between deregulated miRNAs in type I and type II EC, as well as the impact of this dysregulation on EC initiation and progression.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Role of miRNA Dysregulation in Thyroid Cancer Development by Targeting the Main Signaling Pathways

Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and  the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...

متن کامل

microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer.

STUDY QUESTION Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer? SUMMARY ANSWER A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control. The different e...

متن کامل

Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer.

The non-invasive diagnostic tool for early detection of endometrial cancer still limited. The etiology of this disease is believed to be associated with disharmony hormone production. One predominant factor that regulate hormone production is microRNA (miRNAs). Some studies reported that miRNAs play a significant role in the process carcinogenesis. We have identified 12 of miRNAs that potential...

متن کامل

The role of miRNAs as diagnostic and therapeutic biomarkers in various cancers

According to the growing number of cancer fatalities and the complexity of the disease in diagnosis, prognosis and treatment, here we have reviewed one of the helpful and promising factors in the diagnosis and treatment of cancer. Micro-ribonucleic acids (miRNAs) are non-coding ribonucleic acids that are evolutionarily conserved and have a length of 18-25 nucleotides. miRNAs control the express...

متن کامل

miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.

The etiology and development of human cancers that remain little understood might be enlightened by defining tumor suppressor microRNAs (TS-miRNA). In this study, we identified TS-miRNAs silenced by aberrant DNA hypermethylation in endometrial cancer. Functional screening of 327 synthetic miRNAs in an endometrial cancer cell proliferation assay identified 103 miRNAs that inhibited cell growth. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Histology and histopathology

دوره 30 5  شماره 

صفحات  -

تاریخ انتشار 2015